泛亚体育2020NIAN8YUE15RI,FANYATIYUSHENGMINGKEXUEXUEYUAN、LINGNANXIANDAINONGYEKEXUEYUJISHUGUANGDONGSHENGSHIYANSHI、GUANGDONGSHENGNONGYESHENGWUDANBAIZHIGONGNENGYUDIAOKONGZHONGDIANSHIYANSHIDENGYIQUNJIAOSHOU、WENJIKAIJIAOSHOUTUANDUIZAINatureCHUBANJITUANQIXIAGUOJIZHUMINGXUESHUQIKAN Cell Death and Differentiation (SHENGWU1QUTop,IF2019: 10.717)ZAIXIANFABIAOTIWEI“Cell fate determined by the activation balance between PKR and SPHK1”DEYANJIULUNWEN(LUNWENLIANJIEDIZHI: http://www.nature.com/articles/s41418-020-00608-8),JIESHILEXIBAOZAIZHENJUNDUSU、XIJUNZHIDUOTANGDENGXIEPOTIAOJIANXIATONGGUOPKR/ SPHK1XINHAOTONGLUJIAOHUDIAOKONGXIBAODIAOWANGYUCUNHUO,CONGERWEICHIXIBAOWENTAIDEGUANJIANZUOYONGJILI。
XIBAODEJINGSHENGZHANGLVHEJINGSIWANGLVZHIJIANCUNZAIPINGHENG,ZHEIZHONGSHENGLINEIWENTAIHUISUIZHEGEZHONGXIEPOYINZICIJIERFASHENGGAIBIAN。PKRTONGGUOZILINSUANHUAJIHUOJIEDAODEXIBAOSIWANGHUODIAOWANG,SHIXIBAOZAIXIEPOTIAOJIANXIADEHEXINSHANGYOUFANYING。DANGWAIJIEXIEPO(RUOUTUDUSUHEXIJUNZHIDUOTANG)DADAOYIDINGYUZHI,SPHK1NENGGOUXIANGYINGDUOZHONGWAIYUANCIJIERBEILINSUANHUA,JIHUOS1PHECHENG,TONGGUOS1PDE“inside-out”DIAOKONGZHOUJIEDAOXIBAOCUNHUOXIAOYING。BENYANJIUZHENGMINGSPHK1SHIPKRDIWU,ZHEIZHONGPKRJIEDAODESPHK1LINSUANHUAJINYIBUJIHUOLES1P/S1PR1/MAPKs/IKKαSHENGCUNXINHAO。GENGZHONGYAODESHI,JIHUODESPHK1ZUOWEIFUDIAOKONGYINZIZHIJIEJIEHEPKRDEJIMEIJIEGOUYU,YIZHIPKRDEZILINSUANHUA,JIEKANGPKRJIEDAONEIZHIWANGYINGJIIRE1α/XBP1(s)/CHOPDEDIAOWANGXINHAO,CONGERZHONGXINDINGYIZHENJUNDUSUBAOLUDENGXIEPOTIAOJIANXIAXIBAODEMINGYUN。GAIYANJIUJIESHIDEFUFANKUITONGLUDUIYULIJIEXIBAOGOUJIANXINDENEIHUANJINGPINGHENGJUYOUZHONGYAOYIYI,BUJINYOUZHUYUJIASHENDUIPKRHESPHK1JIMEIGONGNENGHEXIBAOSHENGWUXUEGONGNENGDELIJIE,TONGSHIYEWANSHANLEXIBAOYINGJIXINGXIANGYINGZHENJUNDUSUDENGXIEPOYINSUDELILUNJICHU。
BENLUNWENDETONGXUNZUOZHEWEIDENGYIQUNJIAOSHOUYUWENJIKAIJIAOSHOU,DIYIZUOZHEWEI2017JIBOSHISHENGQIAOHAN。GAIYANJIUDEDAOLEGUOJIAZIRANKEXUEJIJIN-GUANGDONGLIANHEJIJINZHONGDIANXIANGMU、GUANGDONGSHENGZIRANKEXUEJIJINTUANDUIXIANGMUHEGUOJIAZHONGDIANYANFAJIHUAKETIDEZHICHI。(WEN/SHENGMINGKEXUEXUEYUAN MUPEIQIANG TU/SHENGMINGKEXUEXUEYUAN QIAOHAN)